Associations between ApoB/ApoA-I Ratios and Metabolic Syndrome and its Components in Patients with Type 2 Diabetes.
10.4093/kdj.2009.33.2.143
- Author:
Jung Eun KIM
1
;
Wha Young KIM
;
Yoon Jung LEE
;
Ji Eun PARK
;
Young Ju CHOI
;
Kap Bum HUH
;
Ji Yun HWANG
Author Information
1. Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea. jiyunhk@gmail.com
- Publication Type:Original Article
- Keywords:
Apolipoprotein A-I;
Apolipoprotein B;
Metabolic syndrome X;
Type 2 diabetes mellitus
- MeSH:
Apolipoprotein A-I;
Apolipoproteins;
Blood Glucose;
Diabetes Mellitus, Type 2;
Fasting;
Female;
Humans;
Life Style;
Male;
Metabolic Syndrome X;
Odds Ratio;
Prevalence;
Risk Factors;
Surveys and Questionnaires
- From:Korean Diabetes Journal
2009;33(2):143-154
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The Apolipoprotein B/apolipoprotein A-I ratio (apoB/apoA-I) is a powerful clinical indicator of metabolic syndrome. However, few studies have searched for an association between ApoB/ApoA-I and metabolic syndrome in Korean patients with type 2 diabetes. We investigated the relation between ApoB/ApoA-I and the risk of metabolic syndrome and its components. METHODS: Subjects were 812 (424 males and 388 females) Korean patients who were being treated for type 2 diabetes at Huh's Diabetes Center in Seoul. The patients were classified into quartiles (lowest:Q1-highest:Q4) of ApoB/ApoA-I by gender. Anthropometric and hematological characteristics and dietary intake using a food frequency questionnaire were assessed. RESULTS: The prevalence of metabolic syndrome in our sample was 47.9% in males and 66.5% in females. The odds ratios (OR) for metabolic syndrome and for having its components were significantly increased from Q2 to Q4 quartiles of ApoB/ApoA-I in males (OR = 5.37; 95% CI = 2.98-9.65 and OR = 7.41; 95% CI = 4.04-13.6) and females (OR = 2.57; 95% CI = 1.28-5.15 and OR = 8.49; 95% CI = 4.28-16.8). These trends withstood adjustment for age, duration of type 2 diabetes, fasting blood glucose levels, and macronutrient intake both in males (OR = 5.24; 95% CI = 2.80-9.24 and OR = 7.98; 95% CI = 4.09-15.6) and in females (OR=4.41; 95% CI = 2.26-8.61 and OR = 8.29; 95% CI = 3.85-17.8). CONCLUSION: ApoB/ApoA-I appeared to be independently associated with risk of having metabolic syndrome and its components in Korean patients with type 2 diabetes after adjustment for putative risk factors including macronutrient intake, a particularly important lifestyle factor for patients with type 2 diabetes. A follow-up study of this population should evaluate the mechanisms underlying the relation between ApoB/ApoA-I and metabolic syndrome and its components.
