Research progress and future perspectives of human pituitary adenoma proteomes
10.3760/cma.j.issn.1008-1372.2016.07.047
- VernacularTitle:人垂体腺瘤蛋白质组研究进展与展望
- Author:
Xiaowei WANG
;
Yun MU
;
Ying LONG
;
Xianquan ZHAN
- Publication Type:Journal Article
- Keywords:
Pituitary neoplasms/ME;
Proteome;
Review
- From:
Journal of Chinese Physician
2016;18(7):1102-1108
- CountryChina
- Language:Chinese
-
Abstract:
Pituitary adenoma is a serious disease that affects human health through interfering hypothalamus-pituitary-target organ axis systems.Proteomics is an effective approach to elucidate molecular mechanisms of a pituitary adenoma and discover effective biomarkers for a pituitary adenoma.A great progress has been made in the field of pituitary adenoma proteomics in the past ten years:(1) the use of laser capture microdissection,(2) functional pituitary adenoma proteomics (such as prolactinoma),(3) proteomics analysis of invasive characteristics of nonfunctional pituitary adenoma,(4) protein post-translational modifications including phosphorylation and tyrosine nitration,(5) the use of protein antibody array,(6) proteomics analysis of hormone isoforms,(7) serum proteomics and peptidomics,(8) integration of proteomics and other omics data,and (9) proposal of multi-parameter systematic strategy for a pituitary adenoma.
