Clinical investigation of diagnosis and differential diagnosis of Ki-67, arginase-1, HepPar-1 and glypican-3 in primary hepatocellular carcinoma
10.3760/cma.j.issn.1008-1372.2016.07.014
- VernacularTitle:Ki-67、Arginase-1、HepPar-1和Glypican-3在原发性肝癌诊断及鉴别诊断中的意义
- Author:
Guihui ZHANG
;
Xiaoqing YANG
;
Yuxia CHENG
;
Qing SUN
- Publication Type:Journal Article
- Keywords:
Liver neoplasms/ME/DI;
Ki-67 antigen/ME;
Arginase/ME;
Glypicans/ME;
Antigens/ME;
Diagnosis,differential
- From:
Journal of Chinese Physician
2016;18(7):1008-1012
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic and differential diagnostic value of Ki-67,Arg-1,HepPar-1 and Glypican-3 in primary hepatocellular carcinoma and benign hepatocellular lesions.Methods A total of 118 cases of primary hepatocellular carcinomas,100 cases of benign hepatocellular lesions and 263 cases malignant carcinomas originated from other organs were adopted in this study.Immunohistochemistry of Ki-67,Arg-1,HepPar-1 and Gly-3 were performed and evaluated in all specimens.Results The expressions of Ki-67 were concordant with the differentiation of hepatocellular carcinomas and the difference between primary hepatocellular carcinomas and benign hepatocellular lesions were statistically significant (P ＜0.01).The combination of Arg-1 + HepPar-1 + Glypican-3 had the most sensitivity and specificity in differential diagnosis between primary hepatocellular and metastatic malignant cancers,while the combination of Ki-67 + Glypican-3 + Arg-1 showed the better diagnostic value in primary hepatocellular carcinomas and benign lesions.Conclusions The application of different immunohistochemical antibody spectra in primary liver cancers could efficiently improve diagnostic accuracy and reliability.
