Effects of lumbar epidural anesthesia on cell apoptosis in rat kidneys with ischemia-reperfusion injury
10.3760/cma.j.issn.1008-1372.2016.07.007
- VernacularTitle:腰段硬膜外麻醉对缺血再灌注损伤大鼠肾脏细胞凋亡的影响
- Author:
Yang LIU
;
Zhigang ZHANG
- Publication Type:Journal Article
- Keywords:
Anesthesia,epidural;
Reperfusion injury;
Kidney/CY/PA;
Apoptosis
- From:
Journal of Chinese Physician
2016;18(7):981-985
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of lumbar epidural anesthesia on cell apoptosis in rat kidneys with ischemia-reperfusion injury.Methods Thirty male Wistar rats were divided into three groups at random,including a sham-operated group,a model group,and an anesthesia group.Then the local norepinephrine,local angiotensin Ⅱ,plasma superoxide dismutase,plasma malondialdehyde and cell apoptosis index were observed at the 24 h after the reperfusion in rat kidneys of ischemia 60 min.Results Compared to the sham-operated group,ischemia-reperfusion of kidney caused a significant increase in contents of local norepinephrine,local angiotensin Ⅱ],and malondialdehyde in the model group and anesthesia group as well as increasing in the cell apoptosis index (P ＜ 0.05),and those parameters above were lower in the anesthesia group than those in the model group (P ＜0.05).Meanwhile,the activities of plasma superoxide were higher than those in model group (P ＜ 0.05).Conclusions The lumbar epidural anesthesia can reduce the excessive accumulation of neuroendocrine hormone in kidney,alleviate oxidative stress,which plays an important role in restraining the ischemia-reperfusion injury and cell apoptosis.
