Study on the dynamic changes of peripheral endothelial progenitor cells in hypertensive cerebral hemorrhage patients

VernacularTitle:外周血内皮祖细胞在高血压性脑出血不同时期患者中的动态变化分析
Author: Jun HANG ; Jiaqiang ZHOU ; Daping WEN ; Gang WANG
Publication Type:Journal Article
Keywords: Endothelial cells; Stem cells; Intracranial hemorrhage,hypertensive/ME
From: Journal of Chinese Physician 2016;18(6):871-874
CountryChina
Language:Chinese
Abstract: Objective To investigate the dynamic changes of endothelial progenitor cells (EPCs) in peripheral blood of patients with hypertensive cerebral hemorrhage.Methods Flow cytometry was used to detect the dynamic changes of EPCs in 79 cases of hypertensive cerebral hemorrhages as the experimental group and 70 cases of normal healthy people as the control group.Results In the acute phase after hemorrhage (3 days),EPCs in experimental group [(51.3 ±9.3) × 103/ml,(52.0 ±6.3) × 103/ml,(53.1 ±9.3) × 103/ml] were significantly lower than the control group [(75.4 ± 15.6) × 103/ml] (P ＜0.05).However,after that the level of EPCs in experimental group [(110.9 ± 12.0) × 103/ml,(132.8 ± 11.8)× 103/ml,(115.3 ±9.9) × 103/ml] increased rapidly and was significantly higher than the control group (P ＜0.05),and approximately two weeks later it reduced to normal levels [(83.1 ±7.9) × 103/ml].Conclusions In patients with hypertensive cerebral hemorrhage,the levels of EPCs in peripheral blood were closely related with the disease and might become a prognostic marker.