Evaluation of the anxiety behavior in acute PD mice induced by MPTP

VernacularTitle:MPTP所致急性帕金森病小鼠焦虑行为的评价
Author: Suzhen YE ; Shuping ZHANG ; Jian SHI ; Yan LIANG ; Hanjin HUANG
Publication Type:Journal Article
Keywords: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/AE; Parkinson disease/CO/ET; Anxiety/CO
From: Journal of Chinese Physician 2016;18(6):865-867
CountryChina
Language:Chinese
Abstract: Objective To investigate the anxious behavior in acute parkinson's mice that were induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection.Methods Twenty mice were randomly divided into the control group (n =10) and model group(n =10);The model group was induced by injecting MPTP dosage,and the control group was induced by the same dose of saline.The anxious behaviors in mice were tested by the elevated plus-maze test and the light/dark box.Results The model group mice spent a longer time than the control group in the dark box (P ＜ 0.05).The open arm entry (OE),open arm time (OT) and OE％ of model group was significantly less than that in control group in the elevated plus-maze test (P ＜ 0.01),the OT％ was significantly less than control group (P ＜0.05).Conclusions Anxiety symptoms appeared in the model group of early parkinson disease (PD)mice.