Study on the correlation between the serum levels of FN-γ, IL-18, IL-10 and recurrent spontaneous abortion

VernacularTitle:血清IFN-、IL-18及IL-10与复发性流产的相关性研究
Author: Lanrong ZHANG ; Xiaoyan MAO ; Ai ZHANG ; Binlie YANG
Publication Type:Journal Article
Keywords: Abortion,habitual/ME; Interferon type Ⅱ/ME; Interleukin-10/ME; Interleukin-18/ME
From: Journal of Chinese Physician 2016;18(6):854-856
CountryChina
Language:Chinese
Abstract: Objective To explore the correlation between the serum levels of interferon (IFN)-γ,interleukin (IL)-18,IL-10 and recurrent spontaneous abortion (RSA).Methods Enzyme-linked immunosorbent assay was used to detect the serum levels of IFN-γ,IL-18 and IL-10.There were 40 patients with RSA (RSA group) and 40 normal early pregnant women (control group) enrolled in this study.After 2 months,those serum cytokines in two groups of non-pregnant state were detected again.Results Compared to control group,the serum levels of IFN-γ and IL-18 of RSA group were significantly higher (P ＜0.01),the serum level of IL-10 was significantly lower (P ＜ 0.01).Two months after termination of pregnancy,there was no significant difference in the serum levels of IFN-γ and IL-10 between the two groups.The serum level of IL-18 maintained a high level in the RSA group after termination of pregnancy.Conclusions In patients with RSA,the serum levels of IFN-γ and IL-18 were elevated,the serum level of IL-10 was decreased.The serum levels of IFN-γ,IL-18 and IL-10 were closely related with RSA.