Application of smell identification test in Parkinson's disease in China
10.3760/cma.j.issn.1006-7876.2016.08.006
- VernacularTitle:嗅觉识别测验在帕金森病患者中的应用
- Author:
Panpan HU
;
Guo FENG
;
Xianwen CHEN
;
Qian YANG
;
Juan FANG
;
Wen ZHOU
;
Kai WANG
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Hyposmia;
Chinese Smell Identification Test
- From:
Chinese Journal of Neurology
2016;49(8):610-614
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the olfactory functions in patients with Parkinson's disease (PD) with a smell identification test developed for the Chinese population and to examine possible factors contributing to PD patients' olfactory performance.Methods Fifty-five patients with idiopathic and nondementia PD and 55 demographically matched healthy controls (HC) were recruited and their olfactory identification tested using the Chinese Smell Identification Test developed by the Institute of Psychology at Chinese Academy of Sciences.Results Olfactory identification score was significantly lower (t =-6.827,P＜0.01) in the PD group (19.3 ±5.4) as compared with the HC group (26.5 ±5.7).Of all PD patients,63.6％ scored over 1 SD below the age norm.In particular,of those with Hoehn-Yahr ratings between 2 to 3,77.8％ scored over 1 SD below the age norm.Receiver operating characteristic (ROC) curve analysis indicated that a cut-off score of 22.5 on the Chinese Smell Identification Test distinguished between PD patients and HC with a sensitivity of 74.6％ and specificity of 70.9％.Within the PD group,age,education,Hoehn-Yahr rating and Mini-Mental State Examination score were not found to correlate with olfactory performance (all P ＞ 0.05).Conclusion PD patients in China show significant impairment of olfactory identification,which is effectively captured by the Chinese Smell Identification Test.
