Ocular manifestations of granulomatosis with polyangiitis: an analysis of 164 patients

VernacularTitle:肉芽肿性多血管炎患者眼部表现临床分析
Author: Di CHEN ; Hanyi MIN ; Jiuliang ZHAO ; Xiaofeng ZENG
Publication Type:Journal Article
Keywords: Wegener granulomatosis; Eye manifestations; Diagnosis
From: Chinese Journal of General Practitioners 2016;15(7):539-542
CountryChina
Language:Chinese
Abstract: Objective To review the ophthalmic features of granulomatosis with polyangiitis (GPA).Methods Clinical data of 164 GPA patients diagnosed in Peking Union Medical College Hospital during the past 10 years were retrospectively reviewed.Results Among 164 patients,48 (29.3％) had ocular involvement with a male to female ratio of 1.4:1 and an average age of (45 ± 15) years.Nine patients (5.5％) were first diagnosed at the ophthalmology department.Scleritis (15.9％,26/164),orbit lesions (13.4％,22/164) and peripheral corneal ulcer (9.1％,15/164) were the three most common ophthalmic complications.Twenty-two patients (13.4％) had positive findings in the orbit imaging.Six patients (3.7％,6/164) lost their vision due to GPA.Conclusion The ocular manifestations of GPA are diverse and complicated.GPA may affect every component of the eye,sclera,orbit and cornea are the most frequently affected sites of the eye.