The relationship between the expression of transient receptor potential vanilioid 1 and the airway remodeling in elderly patients with chronic obstructive pulmonary disease
10.3760/cma.j.issn.0254-9026.2016.05.009
- VernacularTitle:瞬时感受器电位香草酸受体1通道蛋白表达与老年慢性阻塞性肺疾病气道重构的关系
- Author:
Chenci JIN
;
Longxiang JIANG
;
Yufeng ZENG
;
Huanhuan JIANG
;
Ningning YU
- Publication Type:Journal Article
- Keywords:
TRPV cation channels;
pulmonary diseases,chronic;
Airway obstructive
- From:
Chinese Journal of Geriatrics
2016;35(5):490-493
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of trannsient receptor potential vanilloid 1 (TRPV1) and the severity of airway remodeling in elderly patients with chronic obstructive pulmonary disease(COPD).Methods According to airflow obstruction severity,totally 100 cases of elderly patients with COPD were divided into chronic obstructive pulmonary disease Global Initiative(gold) grade 1 in 23 cases,24 cases of grade GOLD2,GOLD3 27 cases,GOLD4 26 cases,respectively.The TRPV1 concentrations in induced sputum supernatant and serum from each level of elderly patients with COPD as well as in 50 cases of healthy old people were analyzed.Results TRPV1 concentrations in serum and induced sputum in the COPD group was significantly increased compared with the healthy elderly group[(9.94±2.91)μg/L vs.(3.68±0.46)μg/L,(3.29± 1.32)μg/L vs.(0.70 ± 0.30)μg/L] (P ＜ 0.01).The serum and induced sputum TRPV1 concentrations in the mutual pairwise comparison between the elderly COPD patients with all levels had statistical difference (P ＜ 0.01).Conclusion The expression of TRPV1 protein become increased with the severity of airway remodeling in elderly patients with chronic obstructive pulmonary disease.
