99Tcm-EHIDA SPECT combined with planar hepatobiliary scintigraphy for the differentiation between infant biliary atresia and neonatal hepatitis
10.3760/cma.j.issn.2095-2848.2016.04.005
- VernacularTitle:99Tcm-EHIDA肝胆平面显像联合SPECT显像对婴儿胆道闭锁和新生儿肝炎的鉴别诊断价值
- Author:
Wenlu ZHENG
;
Yue CHEN
;
Zhanwen HUANG
;
Liang CAI
;
Wenbin DONG
;
Bin LIU
- Publication Type:Journal Article
- Keywords:
Biliary atresia;
Hepatitis;
Infant;
Infant,newborn;
Radionuclide imaging;
Tomography,emission-computed,single-photon;
EHIDA
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2016;36(4):296-299
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of 99Tcm-EHIDA SPECT combined with planar hepatobiliary scintigraphy (combined scintigraphy) in the differentiation of infant biliary atresia (BA) from neonatal hepatitis (NH).Methods This is a retrospective study on 32 infants with cholestasis (18 males,14 females;age:28-83 d) from June 2013 to June 2014.All infants underwent sequential 99Tcm-EHIDA hepatobiliary planar scintigraphy and combined scintigraphy,and the diagnostic efficacy of the 2 methods for differentiating infant BA from NH was analyzed by x2 test.Results In sequential planar scintigraphy,the diagnostic sensitivity,specificity,accuracy,positive predictive value and negative predictive value were 76.2％ (16/21),6/11,68.8％ (22/32),76.2％ (16/21) and 6/11,respectively.In combined scintigraphy,the diagnostic parameters were 95.2％ (20/21),8/11,87.5％ (28/32),87.0％ (20/23) and 8/9,respectively.Combined scintigraphy correctly identified 4 BA cases that were misdiagnosed as NH by planar scintigraphy.The sensitivity of combined scintigraphy was significantly higher than that of planar scintigraphy (x2 =4.285,P＜0.05),while no significant difference was found in the other diagnostic parameters (x2 =0.061-0.405,all P＞0.05).Conclusions Combined scintigraphy has incremental value for the differentiation of infant BA from NH.
