Application of new bifunctional chelator DOTA and its derivatives in the metal radionuclide labeled compounds
10.3760/cma.j.issn.2095-2848.2016.04.023
- VernacularTitle:新型双功能螯合剂DOTA及其衍生物在金属核素标记中的应用进展
- Author:
Fei CHEN
;
Mengjun JIANG
;
Bao ZHU
- Publication Type:Journal Article
- Keywords:
DOTA;
Analogs & derivatives;
Isotope labeling;
Metals;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2016;36(4):371-374
- CountryChina
- Language:Chinese
-
Abstract:
DOTA and its derivatives are most widely uscd novel bifunctional chelators.They have not only mature synthesis route,but also good coordination and chelating ability.Therefore,DOTA metal complexes of DOTA-peptide conjugates are increasingly used as MRI contrast agents,radionuclide targeted imaging agents and therapeutic radiopharmaceuticals in the biomedical field.This review covers the bifunctional derivatives of DOTA,the synthesis of DOTA-peptide conjugates,and the applications of DOTA-peptide conjugate metal complexes.
