A Case of NCAM-positive Nasal Type T/NK-Cell Lymphoma.
10.5021/ad.1998.10.3.190
- Author:
Jae Wang KIM
;
Sang Ho NAM
;
Kwang Joong KIM
;
Chong Min KIM
;
Chong Ju LEE
- Publication Type:Case Report
- Keywords:
Nasal type T/NK-cell lymphoma;
NCAM;
EBV
- MeSH:
Aged;
Forearm;
Gene Rearrangement;
Herpesvirus 4, Human;
Humans;
Lymphoma*;
Male;
Neural Cell Adhesion Molecules;
Skin;
T-Lymphocytes
- From:Annals of Dermatology
1998;10(3):190-194
- CountryRepublic of Korea
- Language:English
-
Abstract:
We herein report a case of nasal type T/natural killer(NK)-cell lymphoma(TNKCL). This lymphoma is characterized by the expression of CD2, CD43 and NCAM(CD56) antigen, an aggressive clinical course, frequent extranodal spreading, a strong association with Epstein-Barr virus(EBV), and the absence of T-cell receptor(TCR) gene rearrangement. NCAM antigen is known to be a possible determinant of extranodal dissemination of peripheral T-cell lymphoma(PTCL). The patient is a 70-year-old male with skin lesion on his forearm. Histopathological and immunohistochemical studies were diagnostic of EBV-associated TNKCL. Untill now, he has failed to respond to anticancer therapy.
