Detecting G6PD deficiency and analyzing variants of DNA mutation of some individuals with G6PD deficiency from Kinh, Muong, Racley, Tay Ethnic groups living Hanoi, Hoa Binh, and Khanh Hoa provinces
- Author:
Tran Thi Chinh
- Publication Type:Journal Article
- Keywords:
G6PD
- MeSH:
Mutation;
Genes;
deficiency;
DNA;
epidemiology
- From:Journal of Medical Research
2003;23(3):98-104
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
In this study, 119 G6DP deficient individuals of 2871 people belong to Kin, Muong, Racley, Tay ethnic groups living around Hanoi, Hoabinh, Khanhhoa were detected as G6PD deficiency. 37 DNA samples of the G6DP deficient individuals (32 cases) and 5 normal people (5 cases) had been analyzed. 7 mutation variants of 30 G6DP deficient individuals had been identified, including Viangchan, Chatham, Chinesse-5, Union, Canton….The G6DP Union and Chinesse-5 were only found in the Muong people, in which G6DP Union was the most predominant mutation of this ethnics (8/18 cases). In addition, there were three Muong-families, two of which had G6DP mutations in both the father and the mother; the rest family, Canton mutation in both the mother and the son.
