Advances in impacts of osteoprotegerin and insulin-like growth factor-1 on bone remodeling in osteoarthritis
10.3760/cma.j.issn.2095-4255.2016.07.018
- VernacularTitle:骨保护素、胰岛素样生长因子-1对骨关节炎骨重建作用的研究进展
- Author:
Hongxia DENG
;
Yunfei YAN
;
Jun YU
- Publication Type:Journal Article
- Keywords:
Osteoprotegerin;
Insulin-like growth factor-1;
Osteoarthritis;
Bone remodeling;
Cartilage
- From:
Chinese Journal of Endemiology
2016;35(7):534-539
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis (OA) is a kind of chronic and frequently-occurring disease in the elderly.It is also called degenerative disease.Pain,stiffness,swelling,deformity and dysfunction of joints are the main clinical manifestations,which seriously affect the quality of life.Kaschin-Beck Disease (KBD) is a kind of endemic diseases;its main feature is cartilage degeneration and necrosis.Although KBD becomes a typical OA in late stage,it is different from OA.Osteoprotegerin (OPG) and insulin-like growth factor (IGF)-1 participate in the bone growth,repair,and alteration.In this paper,we summarized clinical manifestations and pathological changes of OA,and reviewed the current situation and development of OPG and IGF-1 in OA bone remodeling.
