Propofol relaxes mesenteric arteriole via gap junction
- VernacularTitle:不同浓度丙泊酚通过缝隙连接通讯对舒张大鼠肠系膜动脉的影响
- Author:
Huijuan WAN
;
Yanhui LIU
;
Aimei ZHANG
;
Haichao ZHANG
;
Ketao MA
;
Junqiang SI
;
Li LI
- Publication Type:Journal Article
- Keywords:
Propofol;
Mesenteric arterioles;
Gap junction;
Pressure myograph system
- From:
The Journal of Clinical Anesthesiology
2016;32(7):692-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of propofol on mesenteric artery in SD rats and to observe whether the effect of propofol on the mesenteric artery relaxation is related to the gap. Methods Pressure myograph was used to examine the effect of 18β-GA and 2-APB on the relaxation induced by propofol 1×10 -7 ,3×10 -7 ,1×10 -6 ,3×10 -6 ,1 ×10 -5 ,3 ×10 -5 ,1 ×10 -4 and 3 ×10 -4 mol/L in acutely separated mesenteric arterioles of SD rat.Results The diameter of mesenteric arteri-oles were increased from (208.6±13.4)to (213.5±13.6),(21 9.7±13.2),(226.4±12.5),(234.9 ±12.3),(245.5±13.0),(267.4±1 5.2),(336.2±18.3)and (385.9 ±14.2)μm after application of 1×10 -7 ,3×10 -7 ,1 × 10 -6 ,3 × 10 -6 ,1 × 10 -5 ,3 × 10 -5 ,1 × 10 -4 and 3 × 10 -4 mol/L propofol,re-spectively.Propofol induced dilation of the rat mesenteric arterioles in a concentration-dependent man-ner (P < 0.01 ).After pretreatment with 18β-GA and 2-APB,1 × 10 -4 mol/L propofol induced dilation was absolutely decreased (P <0.01).Conclusion These results suggest that propofol relaxes mesenteric arterioles via gap junction.
