DKI study of brain structural changes in patients with chronic alcohol dependence

VernacularTitle:慢性酒精依赖患者脑结构改变的DKI研究
Author: Xiang FAN ; Jun LIU ; Liang XU
Publication Type:Journal Article
Keywords: chronic alcohol dependence; magnetic resonance imaging; diffusion kurtosis imaging; mean kurtosis
From: Journal of Practical Radiology 2016;32(7):1005-1008
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between brain structure abnormalities and neuropsychology impairment in CAD patients.Methods Nineteen patients with CAD and 1 7 healthy adults were examed with MRI,and T1 WI,T2 WI,FLAIR,DWI and DKI image were performed,and then comparing the acquired MRI findings between two groups.Results Significant differences were observed for MK values in splenium and body of the corpus callosum,left cerebellar hemisphere and amygdala cerebelli.MK values of CAD group were lower than those of healthy group in these regions,and differences were statistically significant(P <0.05). There were significant correlation between MK values of the left amygdala cerebelli and MoCA scores in CAD group.Conclusion DKI could detect the changes of brain tissue microstructure in CAD patients early.The correlation between MK and neuropsychologi-cal function provides an important basis for early diagnosis and treatment.