The Difference in the Concentration of Insulin and c-peptide in Portal Vein and Peripheral Blood
- VernacularTitle:门静脉与外周血液胰岛素和C肽浓度的差异性
- Author:
Peng LI
;
Junfeng WANG
;
Jianzhong TANG
;
Ben NIU
;
Ying YANG
- Publication Type:Journal Article
- Keywords:
Portal vein blood;
Peripheral blood;
Insulin;
C-peptide;
Liver function
- From:
Journal of Kunming Medical University
2016;37(6):113-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the concentration changes of insulin and c peptide of in portal vein and peripheral blood, and explore the feasibility of using insulin and c peptide concentration changes in assessment of liver function. Methods The portal vein and peripheral blood samples were extracted from 82 clinical liver cancer patients, and the insulin and c peptide concentration were detected. The differences in the insulin and c peptide concentration in portal vein and peripheral blood were statistically analyzed. Results The insulin concentration in the portal vein and peripheral blood values were 32.43 μ U/ml and 8.05 μ U/ml, respectively, there was a significant difference (P<0.05) . The c-peptide concentration in the portal vein and peripheral blood values were 1.38 μU/mL and 1.19 μg U/mL, respectively, there was no significant differences (P>0.05) . Conclusion Liver metabolizes insulin as the target organ of insulin, while c-peptide dose not be metabolized in vivo, so it is possible to assess liver function by comparative analysis of the metabolic rate of insulin and c-peptide changes.
