Treatment effects of trimetazidine on coronary artery bridge
10.11958/20150145
- VernacularTitle:曲美他嗪治疗冠状动脉肌桥疗效观察
- Author:
Jianyan ZHANG
;
Zhaozeng GUO
;
Tao ZHANG
;
Xuejiao MA
;
Yuejuan CAO
- Publication Type:Journal Article
- Keywords:
coronary artery disease;
cardiomyopathies;
trimetazidine;
exercise tolerance;
coronary myocardial bridge
- From:
Tianjin Medical Journal
2016;44(7):914-916
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the treatment effects of trimetazidine on myocardial bridge. Methods A total of 76 patients with clinical symptoms, such as different degrees of chest tightness, palpitation, breath shortness, chest pain, were diagnosed as coronary myocardial bridge by coronary angiography, and were divided into two groups randomly. While control group (n=40) was given beta-blocker or (and) calcium antagonist as routine treatment. The treatment group (n=36) was given routine treatment and trimetazidine, 20 mg, three times daily. The mean follow-up period was 12 weeks. The episodes of chest pain per week, exercise tolerance, anxiety and depression scores, total ischemic burden in 24 h and walking distance in 6 min were observed in two groups of patients. Results The parameters of chest pain times per week, exercise tolerance, anxiety and depression scores, total ischemic burden in 24 h and walking distance in 6min were improved in treatment group compared with control group, and the symptoms were effectively relieved, the life quality of patients were improved. Conclusion The conventional treatment combined with trimetazidine is safe and effective, which can further improve myocardial energy metabolism and exercise tolerance, and enhance the clinical effect and the life quality of patients.
