The Value of Renal Tubular Injury Biomarkers in Diagnosis of Primary Nephrotic Syndrome
- VernacularTitle:肾小管标记物对原发性肾病综合征诊断价值
- Author:
Yu LIU
;
Dayong HOU
- Publication Type:Journal Article
- Keywords:
Primary nephrotic syndrome;
β2-microglobulin;
Retinol conjugated protein;
N-acetyl-beta-D nucleosidase amino acids;
Cystatin C
- From:
Journal of Kunming Medical University
2016;37(6):105-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of urinary β2-microglobulin (β2-MG) , retinol conjugated protein (RBP), N-acetyl-beta-D nucleosidase amino acids (NAG) and serum cystatin C (Cys C) in patients with primary nephrotic syndrome (PNS), and explore the application value of those indexes in PNS diagnosis. Methods Fifty-three patients with PNS from Sep. 2009 to Sep. 2015 were enrolled in this study, and 40 healthy people were selected as the control group. The levels ofβ2-MG, RBP, NAG in urinary and Cys C in serum were measured in two groups, and the receiver operator characteristic curves (ROC) were drawn out for investigating the diagnostic value of four indexes to PNS. Results The levels ofβ2-MG, RBP, NAG in urinary and Cys C in serum of patients with PNS were significantly higher than control group (P<0.01) . The RBP, NAG and Cys C had the higher efficiency in diagnosis PNS than β2-MG, the differences were statistically significant (P<0.05) . There were no significant differences in diagnosis PNS between RBP, NAG and Cys C (P>0.05) . The area of RBP under the ROC curve was 0.897 (95%CI was 0.807-0.987) bigger than NAG, Cys C andβ2-MG. Conclusionβ2-MG, RBP, NAG in urinary and Cys C in serum have high sensitivity and specificity in diagnosis PNS, monitoring the levels ofβ2-MG, RBP, NAG in urinary and Cys C in serum may be helpful for diagnosis and clinical therapy of PNS.
