Radiosensitization of artemisinin and its derivatives in tumors

VernacularTitle:青蒿素及其衍生物对肿瘤的放疗增敏作用
Author: Yanjun WANG ; Yongxin JIANG ; Shan LIU ; Hong WANG ; Lyu GE
Publication Type:Journal Article
Keywords: Artemisinins; Neoplasms; Molecular mechanisms of phamacological action; Radiation-sensitizing agents; Derivatives
From: Journal of International Oncology 2016;43(8):612-614
CountryChina
Language:Chinese
Abstract: Artemisinin and its derivative is a kind of efficient,quick and low toxicity of anti-malarial drug.In recent years,we find that artemisinin drugs can not only against malaria,but also have pharmacological effects of immunosuppression,antiviral and anticancer.A number of studies have confirmed that artemisinin and its derivatives have the radiosensitization effects in nasopharyngeal carcinoma,cervical cancer,lung cancer and glioma,and their mechanisms are related to decreasing Weel protein expression,increasing Cyclin B1 protein expression,blocking G2-M phase and cell apoptosis.