The value of fecal high mobility group box-1 in early diagnosis and prediction of severity of neonatal necrotizing ;enterocolitis
10.3969/j.issn.1000-3606.2016.07.009
- VernacularTitle:粪便高迁移率蛋白B1在早期诊断和评估新生儿坏死性小肠结肠炎病情中的价值
- Author:
Luquan LI
;
Lijuan LUO
;
Xin LI
;
Xiaowen LI
;
Yalin RAN
- Publication Type:Journal Article
- Keywords:
necrotizing enterocolitis;
high mobility group bor-1;
fecal;
neonate
- From:
Journal of Clinical Pediatrics
2016;34(7):515-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of fecal high mobility group box-1 (HMGB 1 ) in early diagnosis and prediction of the severity of neonatal necrotizing enterocolitis (NEC). Methods From July 2013 to June 2015 , the neonates who had distention, vomit, or gross blood in stool and were suspected of NEC were recruited as NEC group while hospitalized children without abdominal distension, vomiting, bloody diarrhea, or other gastrointestinal symptoms were recruited as the control group. Stool samples were collected on day 1 , 3 , 5 and 7 after admission. The level of HMGB 1 was measured by enzyme linked immunosorbent assay (ELISA). Results In the end, there were 46 cases in NEC group and 15 cases in control group. In NEC group, 29 cases were conifrmed of stageⅠof NEC by abdominal radiograph within 24 h after hospitalized, all of them were deteriorated to stageⅡphase in 4 days, and 10 cases were deteriorated to stageⅢ. Seventeen cases were conifrmed of stageⅡby abdominal radiograph within 24 h after hospitalized, 7 cases were deteriorated to stageⅢ. In 17 stageⅢcases, 11 cases received surgical treatment and 6 cases gave up. Eight cases survived and 3 died after surgery. The levels of HMGB 1 in NEC group on day 1 , 3 , 5 and 7 after hospitalized were higher than those in control group (P
