Variation and clinical signiifcance of serum galectin-3 in children with chronic heart failure
10.3969/j.issn.1000-3606.2016.07.005
- VernacularTitle:慢性心力衰竭患儿血清半乳糖凝集素-3变化及临床意义
- Author:
Song FENG
;
Jindou AN
;
Binglu LI
;
Wei GE
- Publication Type:Journal Article
- Keywords:
galectin-3;
left ventricular remodeling;
chronic heart failure;
child
- From:
Journal of Clinical Pediatrics
2016;34(7):499-502
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the variation of serum galectin-3 and its correlation with ventricular remodeling in children with chronic cardiac failure (CHF). Methods Forty-ifve children with CHF were included and divided into cardiac function II group (n=10 ), III group (n=18 ), and IV group (n=17 ) according to the severity of CHF. The subjects were also divided into endocardial fibroelastosis (EFE) group (n=21 ) and dilated cardiomyopathy (DCM) group (n=24 ) according to primary disease. Thirty health children were included as control group. The level of serum galectin-3 was detected by ELISA. The level of serum NT-pro BNP was measured by radio immunoassay. The index of ventricular remodeling was detected by ultrasonic cardiogram. The correlation of the level of serum galectin-3 with ventricular remodeling and the level of serum NT-pro BNP were analyzed. Results In 45 children ( 19 males and 26 females) with CHF, the mean age was 3 . 42 ± 1 . 89 years. The levels of serum galectin-3 and NT-pro BNP were higher in cardiac function II group, III group, and IV group than those in control group (all P?0 . 05 ). Spearman rank correlation analysis showed that the level of serum galectin-3 was positively correlated with the left ventricular end diastolic diameter, the left ventricular mass, the left ventricular mass fraction, and the level of serum NT-pro BNP (all P?
