Effects of Electro-acupuncture Pretreatment on Interleukin-1β, Interleukin-6 and Apoptosis in Rats after Cere-bral Ischemia-reperfusion Injury
10.3969/j.issn.1006-9771.2016.07.005
- VernacularTitle:电针预处理对大鼠脑缺血再灌注损伤后炎性因子及细胞凋亡的影响
- Author:
Luwen ZHU
;
Tao YE
;
Yunfei JIANG
;
Xiaojun WU
;
Hongyu LI
;
Mingyang SONG
;
Qiang TANG
- Publication Type:Journal Article
- Keywords:
cerebral ischemia-reperfusion;
electro-acupuncture;
pretreatment;
interleukin-1β;
interleukin-6;
inflammatory response;
apoptosis;
rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(7):765-768
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of electro-acupuncture pretreatment on content of interleukin (IL)-1βand IL-6 in serum and ischemic penumbra, and apoptosis in ischemic penumbra in rats after cerebral ischemia-reperfusion injury. Methods Thirty-six male Sprague-Dawley rats were randomly divided into sham group (n=12), model group (n=12), and electro-acupuncture pretreatment group (n=12). The middle cerebral arteries were occluded for 120 minutes and reperfused. Twenty-four hours after reperfusion, the level of IL-1βand IL-6 in serum and brain tissue was detected with enzyme-linked immunosorbent, and apoptosis of ischemic penumbra was detected with TU-NEL. Results The content of IL-1βand IL-6 in the serum and brain tissue, and the number of TUNEL-positive cells decreased in the elec-tro-acupuncture pretreatment group compared with that in the model group (P<0.01). Conclusion Electro-acupuncture pretreatment may in-hibit inflammatory response and apoptosis in cerebral ischemia-reperfusion injury.
