Cancer cachexia and fat loss
10.3969/j.issn.1005-1678.2016.06.02
- VernacularTitle:癌症恶病质与脂肪流失
- Author:
Dong LIU
;
Shuzhen CHEN
- Publication Type:Journal Article
- Keywords:
cancer cachexia;
fat loss;
fat depletion;
lipolysis;
mediator
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):6-9
- CountryChina
- Language:Chinese
-
Abstract:
Cancer cachexia is a state of highly wasting in the terminal stages of cancer, which is characterized by the depletion of adipose tissue, muscle wasting and body weight loss.Loss of fat depots is more prominent than muscle wasting and often precedes.The enhancement of lipolysis, free fatty acids oxidation and white adipose tissue browning, the reduction of lipogenesis, lipid deposition and adipogenesisare important factors causing fat loss.Tumor necrosis factor α, interleukin-6 and zinc α2-glycoprotein are mediators involved in the process of depletion of adipose tissue, thus the drugs targetingthese mediators show a good promise for the treatment of cancer cachexia.The attention paid to the mechanism of depletion of adipose tissue contributes to the development of new therapeutic methods and drugs.
