Therapeutics, genomics and epigenomics of retinoblastoma
10.3969/j.issn.1005-1678.2016.06.01
- VernacularTitle:视网膜母细胞瘤的治疗、基因组学和表观基因组学研究进展
- Author:
Wenping SONG
;
Rongguang SHAO
;
Liang LI
- Publication Type:Journal Article
- Keywords:
retinoblastoma;
therapeutics;
genomics;
epigenomics
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Retinoblastoma is the most common pediatric retinal tumor initiated by biallelic inactivation of the retinoblastoma gene ( RB1 ) , affecting roughly 1 in 15000 children with 1100 new cases each year.In China, RB remains a potentially devastating disease while lack of early diagnosis and aggressive treatment strategies.Moreover, RB patients individually show a variety of drug response to regular systemic chemotherapy since intensive chemotherapy and long-term follow-up are not as readily available.The majority of patients with advanced diseases require enucleation which affects the future quality of children life.Recent studies showed that alterations in genomics and epigenomics of RB play very important roles in RB progress and therapy.We thereby review current understanding changes of genomics and epigenomics in RB as potential prognostic and therapeutic targets.
