Study on the expression of PKM levels in colorectal cancer
10.3969/j.issn.1005-1678.2016.06.12
- VernacularTitle:丙酮酸激酶在大肠癌组织中的表达水平研究
- Author:
Cuiyao WANG
;
Xiaoyu ZHANG
;
Miaomiao TIAN
;
Xiumei ZHANG
- Publication Type:Journal Article
- Keywords:
PKM1;
PKM2;
colon cancer
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):49-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression level of PKM1 and PKM2 in colorectal cancer tissue and explore the relationship between colorectal cancer progression and their expression level.Methods The PKM1 and PKM2 protein expression levels in colorectal cancer tissues and adjacent tissues to carcinoma were determined by Western blot and Immunohistochemisty method, and the relationship with colorectal cancer were discussed. Results Western blot and Immunohistochemisty results all showed that, compared with adjacent noncancerous, the protein level of PKM1 decreases significantly in cancer tissues (P<0.05), while the protein level of PKM2 increases significantly in cancer tissues (P<0.05).The protein level of PKM1 is not relative with age,sex and stage of patients, but the protein level of PKM2 is relative with pTNM(P<0.05).Conclusion Colorectal cancer tissues with low level of PKM1 and high level of PKM2, and PKM2 was related with TNM of patients.
