Treatment of uncomplicated urinary tract infection by relinqing:a systematic review of randomized controlled trials of clinical studies
10.11958/20150252
- VernacularTitle:热淋清制剂治疗单纯性尿路感染随机对照试验的系统评价
- Author:
Xiang PU
;
Liyan ZHANG
;
Fengwen YANG
;
Dongmei XING
;
Junhua ZHANG
- Publication Type:Journal Article
- Keywords:
randomized controlled trial;
Meta-analysis;
Relinqing;
uncomplicated urinary tract infection
- From:
Tianjin Medical Journal
2016;44(8):1048-1052
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the clinical effectiveness and safety of relinqing pharmaceutical preparations for the treatment of uncomplicated urinary tract infection(UTI). Methods The genitourinary infection, urinary tract infection, pyelonephritis, cystitis, stranguria and urethritis were used as key words to search at CNKI,VIP,SinoMed,PubMed,Wan Fang and Cochrane Library Databases up to April 2015. Data of randomised controlled trials (RCTs) comparing treatments using relinqing were included in this study. The quality of the literature was evaluated by the method of Cochrane handbook 5.1.0. Data extraction was carried out independently by two authors. RevMan 5.2 software was used for Meta-analysis. Results Five RCTs were included that involved a total of 471 uncomplicated UTIs. Analysis of four studies showed a higher rates of effectiveness for uncomplicated UTI in the treatment with relinqing plus antibiotics than those of antibiotics alone [RR and 95%CI:1.15 (1.08-1.23), P<0.001]. Analysis of two studies showed a higher rates of bacterial clearance for uncomplicated UTI in the treatment with relinqing plus antibiotics than those of antibiotics alone [RR and 95% CI: 4.04 (1.78-9.16)]. Conclusion Data from five small studies suggest that relinqing as an independent intervention or in conjunction with antibiotics may be beneficial for treating uncomplicated UTIs. However, the small number and poor quality of the included studies meant that it is not possible to formulate robust conclusion on the use of relinqing for uncomplicated UTI either alone or as an adjunct to antibiotics.
