Research progress of the effect of epithelial-mesenchymal transition on diabetic renal interstitial fibrosis

VernacularTitle:上皮间质转化在糖尿病肾病肾间质纤维化中的研究进展
Author: Xiaoting SUN ; Chunlin ZOU
Publication Type:Journal Article
Keywords: Diabetic nephropathy (DN ); Renal interstitial fibrosis (RIF ); Epithelial mesenchymal transition(EMT)
From: Chinese Journal of Diabetes 2016;24(7):655-661
CountryChina
Language:Chinese
Abstract: [Summary] The epithelial‐mesenchymal transition (EMT) is a biological process in which epithelial cells are converted into cells with mesenchymal phenotype in specified physiological and pathological conditions. EM T plays a critical role in proper embryonic development ,tissue regeneration ,cancer metastasis and organ fibrosis. EM T can be divided into three subtypes (Ⅰ ,II and Ⅲ ) based on different biological context ,of which type II EMT contribute importantly to the development of organ fibrosis.Renal interstitial fibrosis (RIF) is an important pathological feature of diabetic nephropathy (DN). The understanding of molecular mechanisms of this process tubular EM T may provide a clue to intervene the development of DN through suppressing EM T and reversing RIF.