Effect of linezolid on serum myocardial enzyme and cerebrospinal fluid lactate dehydrogenase in intracranial infection mice
10.3969/j.issn.1005-1678.2016.06.15
- VernacularTitle:利奈唑胺对颅内感染小鼠血清心肌酶和脑脊液乳酸脱氢酶的影响
- Author:
Hua ZHANG
- Publication Type:Journal Article
- Keywords:
linezolid;
intracranial infection;
myocardial enzyme;
lactate dehydrogenase
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):60-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of linezolid on serum myocardial enzyme and cerebrospinal fluid lactate dehydrogenase (CSF LDH) in intracranial infection mice.Methods The seventy-five mice were divided into five groups randomly: control group, model group, linezolid of high, medium and low dose group.The model of intracranial infection was established by injecting staphylococcus aureus into mice cranium.The mice in linezolid group were treated with different doses of linezolid, the control group and model group were treated with physiological saline.After 15 days with drug, detect the serum myocardial enzyme and CSF LDH level.Results The myocardial enzyme and CSF LDH level of model group were higher than control group obviously (P<0.01); compared with the model group, the myocardial enzyme and CSF LDH level of low dose group have no diffrence;the myocardial enzyme and CSF LDH level of medium dose group were reduced (P<0.05);the high dose group has an obvious reduction in myocardial enzyme and CSF LDH (P<0.01).And the myocardial enzyme and CSF LDH level of high dose group were lower than the low dose group significantly ( P <0.01 ) . Conclusion Linezolid has an exact effect on intracranial infection caused by staphylococcus aureus, with significant dose-effect relationship.
