Efficacy of mometasone furoate aqueous nasal spray combined with loratadine in pediatric allergic rhinitis and its effects on IL-10, IL-17
10.3969/j.issn.1005-1678.2016.06.17
- VernacularTitle:糠酸莫米松鼻喷剂联合氯雷他定治疗小儿变应性鼻炎的临床疗效及对IL－10，IL－17的影响
- Author:
Wen WU
;
Yun ZHANG
- Publication Type:Journal Article
- Keywords:
mometasone furoate aqueous nasal spray;
loratadine;
pediatric allergic rhinitis;
interleukin-10;
interleukin -17
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):67-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the curative efficacy of mometasone furoate aqueous nasal spray combined with loratadine in the treatment of pediatric allergic rhinitis, and its effects on IL-10, IL-17 in serum.Methods 126 patients of pediatric allergic rhinitis who were admitted in our hospital from May 2011 to September 2013 were selected as research objects and randomly divided into treatment group and control group, 63 patients in each group.The control group were treated with loratadine, while the treatment group were treated with mometasone furoate aqueous nasal spray in combination with loratadine.The curative efficacy, scores of clinical symptoms and nasal examination, curing time, medication time and serum IL-10, IL-17 levels were compared between the two groups.Results The total therapeutic efficacy ratio in the treatment group was 98.41%, which was statistically higher than that of 80.95% in the control group (P<0.05).5 weeks after the treatment, scores of sneezing, runny nose, nasal congestion, nasal itching, eye itching and nasal examination in the treatment group were statistically lower than those in the control group (P<0.05).The curing time and medication time in the observation group were statistically shorter than those in the control group ( P <0.05 ) .The inflammatory factors, in comparison with the control group after treatment, the treatment group had statistically higher level of serum IL-10 and lower level of serum IL-17 ( P <0.05 ) . Conclusion Mometasone furoate aqueous nasal spray in combination with loratadine is effective for pediatric allergic rhinitis with a high therapeutic efficacy ratio.And it could significantly improve clinical symptoms, shorten treatment time, increase level of IL-10 and reduce level of IL-17.
