Effects of mesalazine combined with Xianglian pills on cytokines and immunocytes in ulcerative colitis
10.3969/j.issn.1005-1678.2016.06.44
- VernacularTitle:美沙拉嗪联合香连丸对溃疡性结肠炎患者细胞因子及免疫细胞的影响
- Author:
Qiang ZHENG
- Publication Type:Journal Article
- Keywords:
mesalazine;
Xianglian pills;
ulcerative colitis;
cytokines;
immunocytes
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):148-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of mesalazine combined with Xianglian pills on cytokines and immunocytes in ulcerative colitis. Methods A total of 86 patients with ulcerative colitis from our hospital were collected and randomly divided into experimental group and control group with 43 cases in each group.Patients in the control group were treated by mesalazine, patients in the experimental group were treated by mesalazine combined with Xianglian pills treatment.The cytokines and immunocytes levels and efficacy between two groups were compared.Results After treatment, the clinical effective rate of the control group 69.77% was lower than the experimental group 88.37%, with statistical significance ( P <0.05 );compared with the control group, the TNF-αlevel of the experimental group was lower than the control group, IL-2, IL-4 and IL-10 levels were higher than the control group;the serum TFF1 and TFF3 levels were higher than the control group;CD3 +, CD4 +/CD8 +and NK cells levels were higher than the control group, the level of CD8 +was lower than the control group, with statistical significance ( P<0.05 ) .Conclusion Mesalazine combined with Xianglian pills in the treatment of patients with ulcerative colitis could reduce the inflammatory reactions and improve the clinical efficacy, with lower adverse reactions.
