Effect of Mudan granule combined with zinc sulfate on ankle brachial index in diabetic foot dorsal artery sclerosis and its efficacy
10.3969/j.issn.1005-1678.2016.06.45
- VernacularTitle:木丹颗粒联合硫酸锌对糖尿病足背动脉硬化患者踝臂指数的影响及临床疗效
- Author:
Yanan GUO
;
Qiang SUN
- Publication Type:Journal Article
- Keywords:
Mudan granule;
zinc sulfate;
diabetic foot dorsal artery sclerosis;
ankle brachial index
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):151-154
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Mudan granule combined with zinc sulfate on ankle brachial index in the treatment of diabetic foot dorsal artery sclerosis and its efficacy.Methods 66 cases of patients with diabetic foot dorsal artery sclerosis in this study were selected and divided into 2 group, 33 cases in each group.Control group received mecobalamin injection and zinc sulfate tablet and treatment group received Mudan granule on the basis of control gorup.7 days for a course of treatment and patients received continuous treatment of 4 courses.Clinical efficacy, blood glucose, blood lipids, blood rheology, blood flow dynamics of the dorsal artery of the foot, ankle brachial index, and adverse reactions were compared after the treatment.Results Compared with the control group after the treatment, the total effective rate of the treatment group was higher(P<0.05).Compared with the control group, the serum postprandial 2h blood glucose, total cholesterol, triglyceride, low density lipoprotein cholesterol levels were lower(P<0.05), and high density lipoprotein were higher(P <0.05), the levels of whole blood viscosity high, middle and low shear, plasma viscosity, hematokrit and fibrinogen were lower(P<0.05), the serum levels of appeal index were lower(P<0.05), the blood flow of the dorsal artery, the diameter of the blood vessels and the ankle brachial index were higher (P<0.05), the peak velocity of the dorsal foot artery was lower(P<0.05) .There was no significant difference in the incidence of adverse reactions between the 2 groups.Conclusion Mudan granule combined with zinc sulfate tablet in the treatment of diabetic foot dorsal artery sclerosis was effective with high safety and it could improve ankle brachial index.
