Safety and efficacy of rhPro-uk in treatment of STEMI thrombolysis
10.3969/j.issn.1005-1678.2016.06.51
- VernacularTitle:重组人尿激酶原在STEMI溶栓治疗中的安全性和疗效分析
- Author:
Zhengzhong WANG
;
Li WANG
;
Liqun RAN
;
Lian ZENG
- Publication Type:Journal Article
- Keywords:
acute ST segment elevation myocardial infarction;
recombinant human Pro urokinase;
thrombolysis;
safety
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):170-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of recombinant human Pro urokinase ( rhPro-uk) in treatment of patients with acute ST segment elevation myocardial infarction.Methods 90 cases from 2014 to 2015 selected in three hospital diagnosed with STEMI were randomly assigned into experimental group and control group, 45 cases in each test group.Experimental group received rhPro-uk thrombolytic therapy, control group received urokinase thrombolytic therapy, thrombolytic efficacy and incidence of adverse events were observed and compared between two goups.Results After thrombolysis 2 h, ST segment decline ≥50% of patients in experimental group was 80.00%, ST segment completely fall rate was 55.56%, coronary recanalization rate was 77.78%, all significantly higher than that in control group(60.00%, 33.33%, 55.56 %,separately.P<0.05).After thrombolysis 2h, the difference of TIMI grade between two group was significant (Z=-3.198, P<0.05).After thrombolytic therapy, CTn-I, CK-MB peak levels between two groups were not significantly different.The peak time and average time of experimental group were significantly lower than that in control group (P<0.05).The incidence of adverse events of experimental group 13.33%, significantly lower than 33.33% in control group(P <0.05).Conclusion Therapeutic effect of rhPro-uk on acute ST-segment elevation myocardial infarction is better than urokinase, and has higher safety.
