Diagnostic value of carcino embryonic antigen,squamous cell carcinoma antigen, human papilloma virus-E7 in cervical carcinoma
10.3969/j.issn.1005-1678.2016.06.56
- VernacularTitle:癌胚抗原、鳞状细胞癌抗原、HPV－E7蛋白检测对宫颈癌诊断的价值
- Author:
Wen LUO
- Publication Type:Journal Article
- Keywords:
carcino embryonic antigen;
squamous cell carcinoma antigen;
HPV-E7 protein human papillomavirus;
cervical cancer;
diagnosis
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):185-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of carcino embryonic antigen (CEA),squamous cell carcinoma antigen(SCC),human papilloma virus-E7 (HPV-E7) in cervical carcinoma.Methods A total of 107 cases of women patients treated in hospital from July 2013 to July 2015 accorded to the pathological examination results were divided into cervical cancer group 60 cases and CIN group 47 cases,another 50 cases of healthy people were selected as control group, and serum expression levels of HPV-E7, CEA and SCC in the three groups were detected by enzyme-linked immunosorbent assay.Results The serum HPV-E7, CEA and SCC in cervical cancer group were significantly higher than those in CIN group and control group (P<0.05).There was no significant difference in serum HPV-E7, CEA and SCC between CIN group and control group.The levels of serum HPV-E7, CEA and SCC in stage I-II were significantly lower than those of stage III-IV in patients with cervical cancer, and the difference with statistically significant between two groups(P<0.05).The area under the ROC of HPV-E7 was significantly higher than that of CEA and SCC (Z=2.914,2.951, P<0.05), and there was no significant difference in the area under the ROC between CEA and SCC (Z=1.580,P=0.057).Conclusion The serum HPV-E7, CEA and SCC in cervical cancer patients are significantly higher, the diagnosis value of HPV-E7 is higher which is expected to become one of the effective indicators of cervical cancer diagnosis.
