Application of RNA isolating system in blood molecular marker tests
10.3760/cma.j.issn.1009-9158.2016.07.022
- VernacularTitle:RNA 采集系统在血液分子诊断生物标志物检测中的应用
- Author:
Changguo CHEN
;
Qiangyuan ZHAO
- Publication Type:Journal Article
- Keywords:
Biomarker;
Blood sample;
Blood collection system;
Ribonucleic acid
- From:
Chinese Journal of Laboratory Medicine
2016;39(7):559-561
- CountryChina
- Language:Chinese
-
Abstract:
As one important member of the biological sample library , blood samples are rich in biological molecules, which can be used for disease diagnosis , prognosis of disease staging , and prognosis et al.compared with tissue samples, blood samples have some advantages , such as easier to access, sampling in a row and rich test items and so on.However, after blood samples were collected, which need to be processed, packed and frozen in ice for long-term preservation container.Otherwise RNA in the blood sample is unstable and easily degradation in normal temperature transportation and preservation condition , thus subsequently affecting the molecular diagnostic biomarkers ′detection, analysis, research and development.In this paper, This review summarizes the current clinical and research work of routine blood collection and preservation methods effecting on blood RNA degradation and solution for avoiding these degrading which can help testing changings of blood biomarker more accurately .
