Progress on IL 13 and its receptor in the pathogenesis of pulmonary hypertension
10.3760/cma.j.issn.1673-4408.2016.06.004
- VernacularTitle:白细胞介素-13及其受体在肺动脉高压发病中的作用研究进展
- Author:
Li LIU
- Publication Type:Journal Article
- Keywords:
Pulmonary hypertension;
Interleukin-13;
Vascular endothelial cell
- From:
International Journal of Pediatrics
2016;43(6):437-440
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary hypertension is a common clinical disorder and its pathogenesis has not been fully understood.Numerous studies indicate that the mechanisms of inflammation and immune play an important role in pulmonary hypertension.Interleukin(IL)-13 is an important cytokine secreted by the activated Th2 type cells.A recent study has shown IL-13 is a mediation factor that may cause hypertrophy of pulmonary artery smooth muscle cells and endothelial cells.This article reviews the mechanisms of intervention of IL-13 with pulmonary artery smooth muscle cells and endothelial cells in pathpgenesis of pulmonary hypertension.
