Research progress on molecular mechanisms of gastroenteropancreatic neuroendocrine tumors
10.3760/cma.j.issn.1007-8118.2016.08.020
- VernacularTitle:胃肠胰神经内分泌肿瘤形成的分子机制研究进展
- Author:
Meng JI
;
Chenghao SHAO
- Publication Type:Journal Article
- Keywords:
Gastroenteropancreatic neuroencrine tumors;
Molecular mechanisms;
Gene mutations;
Receptors;
Epigenetics
- From:
Chinese Journal of Hepatobiliary Surgery
2016;22(8):572-576
- CountryChina
- Language:Chinese
-
Abstract:
Gastroenteropancreatic neuroencrine tumors (GEP-NETs) originate from the neuroendocrine cells of the digestive system.Over the past few years,the incidence has increased gradually.The clinical manifestations are diverse,and the related molecular mechanism is also more complex.Although there are more and more basic researches for GEP-NETs,the mechanism for carcinogenesis and metastasis has not been fully elucidated.This paper summarizes the latest progress on the development of GEP-NETs,and elaborates the new findings on tumor molecular mechanisms,mainly including the related receptors and its signaling pathways,gene mutations and epigenetic changes.
