Treatment of childhood refractory Langerhans cells histiocytosis
10.3760/cma.j.issn.1673-4408.2016.04.008
- VernacularTitle:难治性儿童朗格汉斯组织细胞增生症的治疗进展
- Author:
Fangfang WU
- Publication Type:Journal Article
- Keywords:
Refractory Langerhans cell histiocytosis;
Therapy;
2-chlorodeoxyadenosine;
Indomethacin;
Children
- From:
International Journal of Pediatrics
2016;43(4):292-295
- CountryChina
- Language:Chinese
-
Abstract:
The definition of refractory Langerhans cells histiocytosis (LCH) is risk organs (bone marrow, liver, spleen)involvement and the first-line treatment failure.It has a very poor prognosis.The survival depends on timely and effective salvage treatment.Currently the treatment for refractory LCH includes isolated 2-chlorodeoxyadenosine, 2-chlorodeoxyadenosine combined with high-dose cytarabine, indomethacin, hematopoietic stem cell transplantation and targeted therapy.In this paper, the advances in treatment of the refractory LCH in children were reviewed.
