Research progress on HOTAIR in tumor biological behaviors
10.3969/j.issn.1000-8179.2016.16.611
- VernacularTitle:HOTAIR与肿瘤生物学行为的研究进展
- Author:
Xuan ZHOU
;
Lingping KONG
;
Lun ZHANG
- Publication Type:Journal Article
- Keywords:
long non-coding RNA;
HOTAIR;
oncogenesis;
metastasis
- From:
Chinese Journal of Clinical Oncology
2016;43(16):731-734
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNA (lncRNA) is a cluster with over 200 bp in length and has no protein-encoding product RNA, which is in-volved in cellular physiological or pathological process, especially in human oncogenesis. HOX transcript antisense RNA (HOTAIR), which is 2158 bp in length, is one of the most well-studied lncRNAs. Overexpression of HOTAIR is correlated with oncogenesis or me-tastasis in numerous epithelium original human cancers, including breast and colorectal cancers. Inhibiting HOTAIR expression could suppress cell growth and invasive ability of tumors. This review provides a brief summary of the latest progress in lncRNA-based can-cer research.
