Expression of Beclin1, p62 and Atg5 in tissue of serous ovarian cancer and its significance

VernacularTitle:自噬相关蛋白Beclin1 、p62、Atg5在浆液性卵巢癌组织中的表达及临床意义
Author: Youhui WANG ; Xien WANG ; Min PENG ; Jing ZHANG
Publication Type:Journal Article
Keywords: Serous ovarian cancer; Autophagy; Beclin1; p62; Atg5
From: Chinese Journal of Endocrine Surgery 2016;10(4):329-332
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of Beclin1,p62 and Atg5 in serous ovarian cancer and its clinical significance.Methods The expression of Beclin1,p62 and Atg5 was detected in 50 serous ovarian cancer tissues by immunohistochemical method,and the relationship between their expression levels and the clinical parameters of serous ovarian cancer patients were analyzed.Results The expression of Beclin1 and Atg5 in serous ovarian cancer tissue was significantly lower than that in normal ovarian tissue,but p62 was significantly higher than that in normal ovarian tissue,and the difference had statistically significance (P＜0.05).The expression of Beclin1 and Atg5 were correlated with degree of cell differentiation and clinical stage (P＜0.05),while the expression of p62 was associated with clinical stages and lymph node metastasis (P＜0.05).Conclusions The abnormal expression of Beclin1,p62,Atg5 in serous ovarian cancer,which can lead to reduced autophagy body formation and autophagy activity,may be involved in the occurrence and development of serous ovarian cancer.