Expression and prognostic role of ADP-ribosylation factor 6 in human endometrial carcinoma
10.3760/cma.j.issn.1674-6090.2016.04.016
- VernacularTitle:ARF6在人子宫内膜癌中的表达及对患者预后的影响
- Author:
Dongmei CHEN
;
Yihong MA
;
Zhenzhen LI
- Publication Type:Journal Article
- Keywords:
ARF6;
Endometrial carcinoma
- From:
Chinese Journal of Endocrine Surgery
2016;10(4):325-328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and prognostic role of ADP-ribosylation factor 6 (ARF6) in human endometrial carcinoma.Methods 51 endometrial carcinoma tissues and matched tumor-adjacent tissues were collected from Jan.2010 to Dec.2011 in People's Hospital of Linzi District of Zibo City and Penglai People's Hospital.mRNA expression of ARF6 was detected by qRT-PCR,and the protein expression of ARF6 was detected by immunohistochemistry.The correlation between ARF6 and clinicopathological features was analyzed by chi-square test,and the Kaplan-Meier survival curves were drawn to describe the prognostic effects of ARF6 expression.Results Both mRNA and protein expression of ARF6 were down-regulated in endometrial carcinoma tissues than those in matched tumor-adjacent tissues (P＜0.05).Positive expression of ARF6 was associated with lynphatic metastasis (P＜0.05) and advanced TNM stage (Ⅲ+Ⅴ,P＜0.05).Both the 3-year overall survival rate and disease-free survival rate were lower in ARF6 positive expression group than in ARF6 negative expression group(P＜0.05).Conclusion Positive expression of ARF6 in human endometrial carcinoma is related to the malignant clinicopathological features and poor prognosis.
