High mobility group box 1 protein and intracerebral hemorrhage
10.3760/cma.j.issn.1673-4165.2016.06.015
- VernacularTitle:高迁移率族蛋白-1与脑出血
- Author:
Limin LI
;
Yingchun ZHAO
- Publication Type:Journal Article
- Keywords:
Cerebral Hemorrhage;
HMGB1 Protein;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2016;24(6):565-568
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group box l protein (HMGB1) is a highly conserved non-histone DNA binding protein,which is widely distributed in eukaryotic cells.HMGB1 is an important proinflammatory cytokine,involving in various pathological and physiological processes,such as inflammation,neurogenesis and angiogenesis.In the early stage of intracerebral hemorrhage,HMGB1 can induce secondary brain injury,such as inflammatory reaction,neuronal necrosis,and brain edema.However,in the late stage of intracerebral hemorrhage,HMGB1 can promote angiogenesis and neurogenesis,and thus improving neurological function.HMGB1 will become a novel therapeutic target for intracerebral hemorrhage in the future.
