A Meta-analysis of Urinary Kallidinogenase Combined with Sodium Ozagrel in the Treatment of Cerebral Infarction
10.3870/j.issn.1004-0781.2016.09.012
- VernacularTitle:尤瑞克林联合奥扎格雷钠治疗脑梗死的 Meta 分析
- Author:
Chao ZENG
;
Jian TANG
;
Caihong TAN
;
Fang ZHENG
;
Gaofeng LIU
- Publication Type:Journal Article
- Keywords:
Urinary kallidinogenase;
Sodium ozagrel;
Infarction,cerebral;
Meta-analysis
- From:
Herald of Medicine
2016;35(9):960-967
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy and safety of urinary kallidinogenase combined with sodium ozagrel for cerebral infarction (CI), and provide references for clinical rational drug use. Methods Retrieved from Cochrane library, PubMed, CBM, FMJS, VIP, Wangfang database and CNKI ( published until January 2015), randomized controlled trails (RCT)about urinary kallidinogenase combined with sodium ozagrel for treatment of CI were included,then methodological quality were evaluated and statistical analysis of those studies were carried out by Rev Man 5.3.4 software. Results 19 RCTs were included,involving 1 747 patients. Results of Meta-analysis showed that urinary kallidinogenase combined with sodium ozagrel could significantly improve total effective rate[RR= 1.18, 95%CI(1.13, 1.23), Z= 7.97, P<0.000 01], cure rate[RR = 1.42, 95%CI(1.23, 1.64), Z= 4.86, P<0.000 1], neurological deficit scores[MD= -4.40, 95%CI(-5.36, -3.43), Z= 8.90,P<0. 000 01] and activity of daily living scores[MD = 19.14, 95%CI(17.39, 20.90), Z = 21.36, P<0.000 01]. Conclusion Urinary kallidinogenase combined with sodium ozagrel was effective in the treatment of CI, and no significant adverse reactions were observed. The combination therapy was worthy of clinical application.
