The Inhibitory Effects of Platelet Glycoprotein IIb/IIIa Receptor Blocker-Coated Stent on Neointima Formation and Inflammatory Response in Porcine Coronary Stent Restenosis.
10.4070/kcj.2003.33.5.439
- Author:
Ok Young PARK
1
;
Myung Ho JEONG
;
Jung Ha KIM
;
Weon KIM
;
Seung Hyun LEE
;
Young Joon HONG
;
Ju Han KIM
;
Woo Suk PARK
;
In Soo KIM
;
Myung Ja CHOI
;
Young Keun AHN
;
Jong Tae PARK
;
Jeong Gwan CHO
;
Dong Lyun CHO
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
1. The Heart Center of Chonnam National University Hospital, Gwangju, Korea. myungho@chollian.net
- Publication Type:Original Article
- Keywords:
Platelets;
Stents;
Coronary restenosis;
Inflammation
- MeSH:
Blood Platelets*;
Constriction, Pathologic;
Coronary Restenosis;
Coronary Vessels;
Follow-Up Studies;
Glycoproteins*;
Hyperplasia;
Inflammation;
Neointima*;
Plasma;
Polymerization;
Polymers;
Stents*;
Transplants
- From:Korean Circulation Journal
2003;33(5):439-445
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Previously, we reported that Abciximab (ReoPro(r))-coated stent inhibited in-stent neointimal hyperplasia. ReoPro(r) is known to suppress vascular inflammation through CD 11b/18 (macrophage-1 receptor). We observed inhibitory effects of neointima formation and inflammatory reaction after stenting in a porcine model. MATERIALS AND METHODS: The surface of the stent was coated with ReoPro(r) by means of plasma polymerization followed by chemical grafting. Stent overdilation injury was performed with control bare stent (Group I, n=13) and ReoPro(r)-coated stents (Group II, n=13) in 26 porcine coronary arteries. Follow-up coronary angiogram and the histopathologic assessments of stented porcine coronary were performed on day 14 (Group I:n=6, Group II:n=6) and day 28 (Group I:n=7, Group II:n=7) after stenting. RESULTS: Pathologic area stenosis was 19.7+/-5.3% in Group I and 15.9+/-3.3% in Group II at day 14, and 33.6+/-27.7% and 22.6+/-6.6%, respectively, at day 28 (p<0.05 at day 28). The ratio of inflammatory cells out of the number of total cells in the neointima was 21.8+/-6.5% in Group I and 22.5+/-11.6% in Group II at day 14, and 27.3+/-18.3% in Group I and 28.6+/-10.7% in Group II at day 28 post stenting (p=NS). And those of the media were 2.89+/-1.13% in Group I and 1.36+/-1.27% in Group II at day 14, and 6.61+/-5.61% and 6.26+/-4.51% at day 28 (p=NS). Fibrinoid materials associated with inflammatory reaction were observed in both groups at days 14 and 28. CONCLUSION: An inflammatory reaction was not suppressed with the use of ReoPro(r)-coated stenting in a porcine stent restenosis model.
