Security Experiment of 2-Methoxyestradiol Nanosuspension
10.3870/j.issn.1004-0781.2016.09.006
- VernacularTitle:2-甲氧基雌二醇纳米混悬剂的安全性实验
- Author:
Xin JIA
;
Chaofeng ZHANG
;
Qingqing ZHANG
;
Shanshan GAO
;
Hanchun YAO
- Publication Type:Journal Article
- Keywords:
2-Methoxyestradiol;
Nanosuspension;
Haemocytolysis;
Anaphylaxis;
Toxicity,acute
- From:
Herald of Medicine
2016;35(9):934-937
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the preclinical safety of 2-methoxyestradiol nanosuspension. Methods The safety of 2-methoxyestradiol nanosuspension for injection was observed through vascular stimulation test of the ear vein on rabbits, hemolytic test using rabbit erythrocytes, active systemic anaphylaxis (ASA) test on guinea pigs and acute toxicity test on mice. Results 2-Methoxyestradiol nanosuspension injection had no irritating effects on vessels, and no haemocytolysis, agglutination and ASA occurred.ASA test showed no allergy symptoms such as piloerection, nose rubbing and dyspnea in guinea pigs 30 min after sensitization.Acute toxicity test revealed that no pathological changes, including black spots and hyperaemia, were visually observed on the heart, liver and lungs after 14 days of intravenous administration. Conclusion 2-Methoxyestradiol nanosuspension injection is relatively safe, with low toxicity, and no hemolytic, anaphylactic and irritating effects. It may be clinically used for injection.
