Application value of atorvastatin combined with anticoagulation drugs in elderly patients with steroid-induced avascular necrosis of the femoral head
10.3969/j.issn.1005-1678.2016.06.33
- VernacularTitle:阿托伐他汀联合抗凝药物在老年激素性股骨头坏死中的应用价值
- Author:
Lihua ZHU
;
Baohua ZHU
;
Minbo LIU
- Publication Type:Journal Article
- Keywords:
atorvastatin;
anticoagulant drugs;
steroid-induced necrosis of the femoral head;
application value
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):115-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the application value of atorvastatin combined with anticoagulation drugs in the treatment of steroid-induced necrosis of the femoral head in the elderly.Methods From February 2013 to January 2016, 112 cases elderly patients accepted treatment of steroid-induced necrosis of the femoral head in our hospital were selected.They were divided into observation group and control group with 56 cases in each group randomly.The two groups were treated with anticoagulant therapy, the observation group received atorvastatin on the basis of control group.The efficacy and indicators between two groups after treatment were compared.Results The excellent and good rate was in observation group was 92.86%, which was higher than 66.07% in control group ( P <0.05 ) .The pain degree, walking ability and total joint mobility score of the observation group were significantly higher than those in the control group(P<0.05).After treatment, plasma viscosity and hematocrit of the observation group were significantly lower than the control group(P<0.05).The time of collapse of the femoral head and the index of necrosis of the observation group were significantly lower than the control group(P <0.05).Conclusion Atorvastatin combined with anticoagulant drugs in the treatment of elderly patients with steroid-induced femoral head necrosis has significant effect, could effectively improve the quality of life of patients with good safety, high application value.
