Effects of dexmedetomidine anesthesia on surgery condition, RAAS activity and renal function in laparotomy

VernacularTitle:右美托咪定麻醉对开腹手术患者手术情况、RAAS活性及肾功能的影响
Author: Qingquan HE ; Yulian QU
Publication Type:Journal Article
Keywords: dexmedetomidine; laparotomy; renin-angiotensin-aldosterone system; renal function
From: Chinese Journal of Biochemical Pharmaceutics 2016;36(6):103-105
CountryChina
Language:Chinese
Abstract: Objective To study the effect of dexmedetomidine anesthesia on surgery condition, renin-angiotensin-aldosterone system (RAAS) activity and renal function of laparotomy patients.Methods 96 patients received laparotomy in our hospital during May 2012 to October 2015 were studied, which were divided into dexmedetomidine group (D group) and control group (C Group) by random number table method and received different anesthetic regimes.Then surgery condition, renal function indexes and plasma renin, angiotensin II levels of two groups were compared.Results The operation time, intraoperative blood loss, intraoperative transfusion volume and awakening time of D group and C group had no significant difference.10 min after opening abdomen and 10 min before closing abdomen, the plasma renin, angiotensin II, cystatin C (Cys-C),α1-microglobulin (α1-MG) contents were significantly lower than those of C group(P<0.05).Conclusion Dexmedetomidine anesthesia applicated in laparotomy could inhibit the RAAS activity, protect renal function, and its anesthesia effect is more precise.