Effects of tiotropium bromide combined with aminophylline on serum BNP, PCT and lung function in senile chronic obstructive pulmonary disease
10.3969/j.issn.1005-1678.2016.06.23
- VernacularTitle:噻托溴铵联合氨茶碱对老年慢性阻塞性肺病患者血清脑钠肽、降钙素原及肺功能的影响
- Author:
Xiaochi WU
;
Wenchao GU
- Publication Type:Journal Article
- Keywords:
tiotropium bromide;
aminophylline;
chronic obstructive pulmonary disease;
brain natriuretic peptide;
procalcitonin;
lung function
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):85-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of serum brain natriuretic peptide(BNP), procalcitonin (PCT) and lung function by tiotropium bromide combined with aminophylline in the treatment of senile chronic obstructive pulmonary disease.Methods A total of 82 cases of elderly patients with chronic obstructive pulmonary disease ( COPD) were collected and randomly divided into experimental group and control group with 41 cases in each group.Patients in the control group were treated by conventional treatment; patients in the experimental group were treated on the basis of the control group with tiotropium bromide combined with aminophylline.The lung function, respiratory condition and serum levels of PCT, BNP before and after treatment were determined, and the clinical efficacy and safety was compared.Results The effective rate of the control group (68.29%) was lower than the experimental group (87.80%) , with statistical significance ( P<0.05 ); compared with the control group after treatment, the forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and FEV1%pre of the experimental group significantly increased, dyspnea score decreased, 4 min walking test increased, serum PCT and BNP levels decreased in the experimental group, with statistical significance ( P<0.05 ). Conclusion Tiotropium bromide combined with aminophylline in the treatment of senile chronic obstructive pulmonary disease could reduce the serum BNP and PCT levels and improve lung function.
