Effect of ipratropium bromide combined with budesonide/formoterol fumarate inhalation powder on serum IgE,FeNO and lung function of bronchial asthma patients
10.3969/j.issn.1005-1678.2016.06.25
- VernacularTitle:溴化异丙托品联合布地奈德／福莫特罗粉吸入剂对支气管哮喘患者血清IgE、FeNO及肺功能的影响
- Author:
Yu JIANG
;
Caiqing ZHANG
- Publication Type:Journal Article
- Keywords:
ipratropium bromide;
budesonide/formoterol fumarate powder for inhalation;
bronchial asthma;
pulmonary function;
FeNO
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):91-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ipratropium bromide combined with budesonide /formoterol fumarate inhalation powder on serum FeNO and lung function of bronchial asthma patients.Methods 102 cases with clear bronchial asthma during Jan 2013 and Mar.2015 from the affiliated Qianfo Hill Hospital of Shandong University were randomly divided into three groups, control group A (34 cases) were treated with ipratropium bromide, control group B (34 cases) were treated with budesonide/formoterol fumarate powder, experiment group (34 cases) were given ipratropium bromide combined with budesonide/formoterol fumarate powder, all groups were treated for 6 months.Pulmonary function, serum FeNO and IgE levels, clinical efficacy were compared after treatment.Results The effective rate of control group A, B (70.59%, 67.65%) were significantly lower than experiment group (91.18%), the difference were significant (P<0.05).FEV1, FVC, FEV1%pre of experiment group were significantly higher than control group A and B after the treatment.Serum IgE and FeNO concentration were significantly lower than control group A, B, the difference were significant ( P<0.05 ) .Conclusion Ipratropium bromide combined with budesonide/formoterol fumarate powder for inhalation in bronchial asthma patients can effectively reduce FeNO concentration, improve lung function.
